Instructor

Edward Breitschwerdt, DVM
Melanie S. Steele Professor of Medicine and Infectious Diseases
Comparative Medicine Institute
NCSU College of Veterinary Medicine

Description

This module provides an overview of Bartonella spp. infection, both pathogenic and species-adapted, in various hosts and reservoirs, including bats, cats, dogs, and people.

Learning objectives

  1. Recognize Bartonelloses in humans
  2. Avoid Bartonelloses in humans by providing preventative techniques through counseling

Accreditation Statement

This session, Bartonelloses Reservoir Hosts: Bats, Cats, Dogs, Mice and Men, is approved for 1.0 enduring AAFP Prescribed credits.

The AAFP has reviewed One Health Medical Education for a Changing Climate, and deemed it acceptable for AAFP credit. Term of approval is from 01/01/2025 to 12/31/2025. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AAFP Prescribed credit is accepted by the American Medical Association as equivalent to AMA PRA Category 1 credit(s)™ toward the AMA Physician’s Recognition Award. When applying for the AMA PRA, Prescribed credit earned must be reported as Prescribed, not as Category 1.



Evidence-based bibliography for further study

  • Bai, Y., Kosoy, M.Y., Boonmar, S., Sawatwong, P., Sangmaneedet, S. and Peruski, L.F., 2010. Enrichment culture and molecular identification of diverse Bartonella species in stray dogs. Veterinary microbiology, 146(3-4), pp.314-319. 
  • Balakrishnan, N., Musulin, S., Varanat, M., Bradley, J.M. and Breitschwerdt, E.B., 2014. Serological and molecular prevalence of selected canine vector borne pathogens in blood donor candidates, clinically healthy volunteers, and stray dogs in North Carolina. Parasites & vectors, 7(1), pp.1-9. Breitschwerdt et al. Parasites and Vectors 2010
  • Daszak, P., Cunningham, A.A. and Hyatt, A.D., 2000. Emerging infectious diseases of wildlife–threats to biodiversity and human health. science, 287(5452), pp.443-449.
  • Inoue, K., Maruyama, S., Kabeya, H., Hagiya, K., Izumi, Y., Une, Y. and Yoshikawa, Y., 2009. Exotic small mammals as potential reservoirs of zoonotic Bartonella spp. Emerging infectious diseases, 15(4), p.526. 
  • Kordick, D.L., Brown, T.T., Shin, K. and Breitschwerdt, E.B., 1999. Clinical and Pathologic Evaluation of ChronicBartonella henselae or Bartonella clarridgeiaeInfection in Cats. Journal of clinical microbiology, 37(5), pp.1536-1547. 
  • Kordick, D.L., Wilson, K.H., Sexton, D.J., Hadfield, T.L., Berkhoff, H.A. and Breitschwerdt, E.B., 1995. Prolonged Bartonella bacteremia in cats associated with cat-scratch disease patients. Journal of Clinical Microbiology, 33(12), pp.3245-3251.
  • Kosoy, M., Bai, Y., Sheff, K., Morway, C., Baggett, H., Maloney, S.A., Boonmar, S., Bhengsri, S., Dowell, S.F., Sitdhirasdr, A. and Lerdthusnee, K., 2010. Identification of Bartonella infections in febrile human patients from Thailand and their potential animal reservoirs. The American journal of tropical medicine and hygiene, 82(6), pp.1140-1145. 
  • Lashnits, E., Correa, M., Hegarty, B.C., Birkenheuer, A. and Breitschwerdt, E.B., 2018. Bartonella seroepidemiology in dogs from North America, 2008–2014. Journal of veterinary internal medicine, 32(1), pp.222-231.
  • Lin, E.Y., Tsigrelis, C., Baddour, L.M., Lepidi, H., Rolain, J.M., Patel, R. and Raoult, D., 2010. Candidatus Bartonella mayotimonensis and endocarditis. Emerging infectious diseases, 16(3), p.500. 
  • Maggi, R.G., Kosoy, M., Mintzer, M. and Breitschwerdt, E.B., 2009. Isolation of Candidatus Bartonella melophagi from human blood. Emerging infectious diseases, 15(1), p.66. 
  • Perez, C., Maggi, R.G., Diniz, P.P.V.P. and Breitschwerdt, E.B., 2011. Molecular and serological diagnosis of Bartonella infection in 61 dogs from the United States. Journal of veterinary internal medicine, 25(4), pp.805-810. 
  • Varanat, M., Maggi, R.G., Linder, K.E., Horton, S. and Breitschwerdt, E.B., 2009. Cross-contamination in the molecular detection of Bartonella from paraffin-embedded tissues. Veterinary pathology, 46(5), pp.940-944. 
  • Veikkolainen, V., Vesterinen, E.J., Lilley, T.M. and Pulliainen, A.T., 2014. Bats as reservoir hosts of human bacterial pathogen, Bartonella mayotimonensis. Emerging infectious diseases, 20(6), p.960. 
  • Welch, D.F., Carroll, K.C., Hofmeister, E.K., Persing, D.H., Robison, D.A., Steigerwalt, A.G. and Brenner, D.J., 1999. Isolation of a New Subspecies, Bartonella vinsoniisubsp. arupensis, from a Cattle Rancher: Identity with Isolates Found in Conjunction with Borrelia burgdorferiand Babesia microti among Naturally Infected Mice. Journal of Clinical Microbiology, 37(8), pp.2598-2601.


Edward B. Breitschwerdt, DVM

About the Instructor

Edward B. Breitschwerdt, DVM

Melanie S. Steele Professor of Medicine and Infectious Diseases, NSCU College of Veterinary Medicine

Dr. Breitschwerdt is a Professor of Medicine and Infectious Diseases at North Carolina State University College of Veterinary Medicine and an Adjunct Professor of Medicine at Duke University Medical Center. He directs the Intracellular Pathogens Research Laboratory in the Center for Comparative Medicine and Translational Research at North Carolina State University and co-directs its Vector Borne Diseases Diagnostic Laboratory. He has contributed to cutting-edge research in the areas of animal and human Bartonellosis and has authored numerous book chapters and proceedings. His research group has published more that 400 manuscripts in peer-reviewed scientific journals.